Fired at the muzzle, a representative .22 LR load (2.6 g, FMJ, 330 m/s) reaches roughly 14 mm (0.6 inches) into polycarbonate. That is enough to defeat a typical barrier of this material — treat anything behind it as exposed.
About Polycarbonate
A polycarbonate pane (~12 mm); true bullet-resistant glass is far thicker and layered.